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| 1846 |
| | | Francis Parkman travels west into dangerous territory in Wyoming, an adventure he later describes in The Oregon Trail | |
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| c. 1846 |
| | | The Irish, fleeing from the potato famine at home, become the main group of immigrants to the USA | |
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| 1846 |
| | | The minority of Conservatives supporting Peel become a separate faction, henceforth known as the Peelites | |
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| 1846 |
| | | Edward Lear publishes his Book of Nonsense, consisting of limericks illustrated with his own cartoons | |
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| 1846 |
| | | The Oregon Treaty establishes the border between Canada and the USA along the 49th parallel to the Pacific | |
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| 1846 |
| | | President Polk sends a US army into Texas, provoking the Mexican-American War | |
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| 1846 |
| | | With his Conservative party split, Peel's government falls and Lord John Russell becomes British prime minister at the head of a Whig administration | |
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| 1846 |
| | | Brigham Young leads the migration of Mormons west up the Missouri from Illinois | |
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| 1846 |
| | | Mendelssohn's oratorio Elijah has its premiere in England, in the city of Birmingham | |
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| 1846 |
| | | After marrying secretly, the English poets Robert Browning and Elizabeth Barrett go abroad to live in Florence | |
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